Aquagenic pruritus is a skin condition characterized by the development of severe, intense, prickling-like epidermal itching without observable skin lesions and. Aquagenic pruritus is probably common, but it is generally unrecognised and may be misdiagnosed. Antihistamines may induce a good. Background: Aquagenic pruritus is characterized by pruritus after contact with water; there are no objective cutaneous changes. Capsaicin, which induces the.

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Aquagenic pruritus is a skin disease characterized by the development of severe itching on contact with water without observable skin lesions.

The symptoms may be felt immediately after contact with water and can persist for an hour or longer. In some families, a tendency toward aquagenic pruritus appears to be hereditary. It may sometimes be a symptom of primary polycythemia or polycythemia vera. We report this case as psychological factors played a role in inciting the condition.

A year-old woman presented with a 6-year history of pruritus predominantly over the lower half of the body after bathing. The pruritus usually started within a minute and regressed after an hour. Itching was precipitated by cold water, and bathing in lukewarm water gave temporary relief. The pruritus was not associated with any urticarial wheals.

The patient was not relieved with various antihistamines since pruritue years. She had aquageni headache and breast tenderness more during the premenstrual period. Her complete blood count, liver and renal function tests were within normal limits. She was treated with antipruritic lotion combination of menthol, calamine and camphor.

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Her symptoms improved the next day but exacerbated the following day. Since her symptoms were exaggerated and did not respond to conventional treatment, a psychiatric opinion was sought. The psychiatrist was able to elicit history of multiple premarital contacts few years back about which she felt guilty.

She was married for 7 years. She was diagnosed to have venerophobia with hypochondriasis and aquageni depression. She was then started on Tab. Sertraline 50 mg and Tab. Quetiapine mg and the patient improved. Visual analogue scale for pruritus was taken before and few days after the treatment and she showed marked improvement. On follow-up, her symptoms had subsided. Aquagenic pruritus is a distressing condition for both the patients and the treating physician. The exact pathogenesis of aquagenic pruritus is unknown.

According to Greaves et al. Various therapeutic modalities have been tried to relieve pruritus. Antihistamines are the mainstay of treatment.


Topical hyoscine has also been proven to be effective in relieving the pruritus. The psychological aspect as a cause in aquagenic pruritus is aquageenic unexplored.

Guilt is a cognitive or an emotional experience that occurs when a person realizes or believes that they have violated a moral standard, and is responsible for that violation. Our patient had premarital contacts which made her feel guilty. Aquagenic pruritus could have been the somatic manifestation of the depressive disorder which improved with treatment. We report this case primarily to highlight the fact that psychological disorders may present with features highly suggestive of known clinical entity.


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Journal List Indian J Dermatol v. Author information Copyright and License information Disclaimer. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. Sir, Aquagenic pruritus is a aquageniv disease characterized by the development of severe itching on contact with water without observable skin lesions.

Aquagenic pruritus

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J Am Acad Dermatol. Aquagenic pruritus and hepatitis. Internist Berl ; Aquagenic pruritus due to use of bupropion. Aquagenic pruritus associated with the idiopathic hypereosinophilic syndrome. Increased cutaneous fibrinolytic activity in aquagenic pruritus. Prevalence and characteristics of aquagenic pruritus in a young African population. Wolf R, Krakowski A. Variations in aquagenic pruritus and treatment alternatives. Ingber S, Cohen PD.

Successful treatment of refractory aquagenic pruritus with naltrexone. J Cutan Med Surg. Support Center Support Center. Please review our privacy policy.