Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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Antibacterial activity of silver nanoparticles synthesized by using whole plant extracts of Clitoria ternatea. In the case of the RD cell line, the Cotula cinerea hexane extract showed the higher cytotoxic effect followed by the ethyl acetate, the essential oil, and the n -butanol extract.

By clicking accept cootula continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. The extraction was achieved during six hours and the obtained oil yield 0.

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The absorbance of the formazan will then be determined by spectrophotometry at nm. The tentative global mechanism gathered probably all these actions which are thus supposed to provide the observed cytotoxic effect. After 30 minutes of incubation at room temperature, absorbance was measured at nm using an ELISA cineera reader.

Articles with ‘species’ microformats Commons category link is on Wikidata Taxonbars with 20—24 taxon IDs Taxonomy articles created by Polbot. In the case the RD cell line, the lowest IC 50 value Evaluation of the Cytotoxicity Before evaluating the antiproliferative activity, ciberea cellular density of each species was determined using light microscopy. Examination of the cytotoxic activity of the Cotula cinerea individual compounds would give crucial information regarding the exact mechanism of this plant in antitumor activity.

Cotula australis Sieber ex Spreng. Despite the appreciable advancements and progress made in cancer treatment, it continues to constitute a serious global health problem, especially with the appearance ctula multidrug resistance cells.


Abstract The objective of this work was to investigate the cytotoxicological effect of the extracts hexane, ethyl acetate, and n -butanol of Cotula cinerea and Salvia verbenaca in addition to the essential coula of Cotula cinerea. Skip to search form Skip to main content.

The hexane, ethyl acetate, and n -butanol extraction yields were, respectively, 1. Morocco is rich in medicinal cotul on which some studies have been focused on antitumor activities [ 7 — 10 ].

To date various bioactive compounds have been tried against cancer. These plants are widely used in the Moroccan traditional folk medicine.

The action and mechanism of Cotula cinerea essential oil is very complex involving several targeting pathways as previously reported [ 5 ]. Prolonged cancer treatment is generally costly to patients and complicates patient follow-up in hospital.

In the same conditions and for the Vero cell line, the best cytotoxic effect was observed with the essential oil followed by the hexane, the ethyl acetate, and the n -butanol extracts. However, the minor compounds could also be of crucial importance; all the phytochemicals could synergistically act and enhance the observed activity [ 14 ].

The noticed differences in the observed cytotoxicity of the investigated mixtures could obviously be due to the phytochemical composition of each extract.

BioMed Research International

By using this site, you agree to the Terms of Use and Privacy Policy. The obtained findings for the two cell lines RD and Vero are summarized in Figures 1 and 2respectively.

The results are expressed as percentage of cytotoxicity cinegea the concentrations of the essential oil or extracts of both plants. In the same conditions, higher concentrations were needed in the case of Salvia verbenaca extracts. The enumeration of cells was made using Malassez cell count.

References Publications referenced by this paper. Oils, Volatile Search for additional papers on this topic. For both lines, an increase of the cytotoxicity with the concentration of the essential oil or the used extracts was observed indicating a dose dependent effect. Table of Cotuoa Alerts. Cotula is the largest genus found in the Southern Hemisphere of the tribe Anthemideae.


The concentrations that cinreea half of cinrea cell population IC 50 were obtained by modeling the percentage of cytotoxicity versus concentration of extracts. Cineea the case of the Vero tumor cell line, Table 1 reveals that Cotula cinerea essential oil showed the highest cytotoxic capacity with the lowest IC 50 value Sports Turf Research Institute.

The biological activity of C. The antiproliferative activity of Cotula cinerea essential oil against the Vero tumor cell line could be due to presence of cytotoxic molecules in the oil. Views Read Edit View history. Salvia verbenaca is corula Mediterranean plant currently belonging to the Lamiaceae family. The essential oil of Cotula cinerea aerial parts was extracted by hydrodistillation using a Clevenger-type apparatus.

Cotula is a genus of flowering plant in the sunflower family. Cotula is known to be used in New Zealand as ground cover for bowling greens, playing fields on which the ball-game of bowls is played [6] [7].

Cotula — Wikipédia

The obtained values are correlated with the metabolized intracellular MTT concentrations and are therefore proportional to the number of living cells. Phillips Cotula pterocarpa DC. Exploring alternative sources of new antitumor agents with specific targets is thus imperative and of great and crucial importance.

Indeed, the antitumor properties of phenolic compounds and flavonoids against several cell lines representing numerous human cell lines have been previously reported [ 6 ]. The essential oil and the ethyl acetate extract showed moderate cytotoxic effects These compounds could act individually or in a synergic manner.