Erythema multiforme is divided into major and minor forms and is now regarded as distinct from Stevens–Johnson syndrome (SJS) and toxic epidermal. dermal necrolysis, where erythema multiforme minor is the mildest type .. Gavaldá-Esteve C, Murillo-Cortés J, Poveda-Roda R. Eritema multiforme. Revisión y. Find out about erythema multiforme, a skin reaction that usually causes a rash for a few weeks.

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Erythema multiforme: MedlinePlus Medical Encyclopedia

A systemic, serious, and life-threatening disorder characterized by lesions in the skin and mucous membranes that may lead to necrosis. As the rash goes away which usually takes a couple of weeksit may turn a brownish color.

Arch Dermatol ; The role of systemic corticosteroid therapy in erythema multiforme major and Stevens-Johnson syndrome: Pale edematous ring Outer: Individuals with persistent chronic erythema multiforme will often have a lesion form multifomre an injury site, e. When to Contact a Medical Professional.

Started inthis collection now contains interlinked topic pages divided into a tree of 31 specialty books and chapters.

Back Links pages that link to this page. Mucosal changes, if present, consist initially of redness of the lips and inside cheek. J Oral Pathol Med.

Labs No lab tests are specific for Stevens Johnson Syndrome. A disorder characterized by target lesions a pink-red ring around a pale center. In rare cases, it is caused by certain medicines or body-wide systemic illness.

It often takes on mimor classical “target lesion” appearance, [4] with a pink-red ring around a pale center. Good hygiene and staying away from other people may help prevent secondary infections infections that occur from treating the first infection. Dermatophyte fungal infections tinea have also been reported in association with erythema multiforme. Many suspected aetiologic factors have been reported to cause EM.


Erythema multiforme—response to corticosteroid. Erythema multiforme minor Erythema multiforme major Stevens—Johnson syndromeToxic epidermal minlr panniculitis Erythema nodosum Acute generalized exanthematous pustulosis. Aphthous stomatitis oral candidiasis lichen planus eritdma pemphigus vulgaris mucous membrane pemphigoid cicatricial pemphigoid herpesvirus coxsackievirus syphilis systemic histoplasmosis squamous-cell carcinoma.

Definition MSH An exfoliative disease of skin seen primarily in adults and characterized by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. There is a genetic tendency to erythema multiforme. If a drug cause is suspected then the possible offending drug should be ceased. Urticaria and erythema L50—L54, Further studies need to address the benefit of steroids, and in the interim, physicians should decide on a treatment based on the severity of EM and in consultation with a dermatologist, if available.

Steroids in children with erythema multiforme. For more detail, see: Differentiating EM and Stevens-Johnson syndrome Although previously thought to be on a similar continuum of EM, and histologically appearing the same, 1 Stevens-Johnson syndrome SJS is increasingly being considered a separate disease process. This can be severe and require hospitalisation due to difficulty eating and drinking.

Clinical features, diagnosis, and treatment of erythema multiforme: Scully C, Bagan J. The target shapes sometimes have blisters or scabs in the middle. These images are a random sampling from a Bing search on the term “Erythema Multiforme.

Erythema Multiforme

Typically in erythema multiforme, few to hundreds of skin lesions erupt within a hour period. These things can provide relief from pain or itchiness, but they won’t make the rash go away any faster. Diagnosis Clinical diagnosis Skin biopsy confirms the diagnosis Apoptosis and necrosis Keratinocyte vacuolization Dermal-epidermal separation Perivascular Lymphocyte infiltration. In cases where the herpes simplex virus is thought to be causing the rash to return, doctors might prescribe a daily antiviral medicine.


The blotches develop over a few days into round target often called “bulls-eye” shapes with red, pink, and pale rings. Treatment of Skin Disease: Back Links pages that link to this page.

DermNet NZ does not provide an online consultation service. EM is a type of allergic reaction.

Although the full mechanism is not understood, it is in part due to a type IV hypersensitivity immune response, mediated by T lymphocytes. Erythema multiforme minor usually resolves spontaneously without scarring over 2—3 weeks.

The patient may have difficulty speaking or swallowing due to multifodme. The typical target lesion also called iris lesion of erythema multiforme has a sharp margin, regular round shape and three concentric colour zones:. Current recommendations suggest not to treat EM minor with systemic steroids and that topical steroids might be of benefit. Erythema multiforme usually starts off looking like pink or red blotches. EM; Erythema multiforme minor; Erythema multiforme major; Erythema multiforme minor – erythema multiforme von Hebra; Acute bullous disorder – erythema multiforme; Herpes simplex – erythema multiforme.

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